Table 2.
Recessive Model for the GSTP1 SNP
| FEV1 | FVC | Dlco | FEF25–75 | FEV1/FVC | TLC | |||
|---|---|---|---|---|---|---|---|---|
| Decline in PFT z-score at each year compared to baseline (pre-SCT) |
1- year |
W/W (n=9) | 3.05 (0.54) |
1.89 (0.56) | 0.05 (0.93) | 0.81 (0.32) | −0.09 (0.35) | 0.19 (0.10) |
| W/V and V/V (n=23) |
1.54 (0.41) |
1.08 (0.42) | −0.54 (0.79) | 0.09 (0.25) | −0.27 (0.26) | 0.11 (0.08) | ||
| Adj P-value | 0.0052 | 0.1234 | 0.4402 | 0.0205 | 0.5683 | 0.3358 | ||
| 2- year |
W/W (n=5) | 1.17 (1.11) |
1.07 (1.13) | 0.09 (0.92) | 0.24 (0.87) | 0.30 (0.68) | 0.06 (0.10) | |
| W/V and V/V (n=11) |
0.76 (0.92) |
0.84 (0.94) | 0.03 (0.65) | 0.06 (0.72) | 0.03 (0.57) | 0.06 (0.09) | ||
| Adj P-value | 0.6057 | 0.7750 | 0.9620 | 0.7761 | 0.5900 | 0.9360 | ||
| 3- year |
W/W (n=2) | 2.13 (0.79) |
−0.26 (0.94) | −2.56 (1.30) | 0.41 (0.59) | 0.20 (0.57) | 0.36 (0.19) | |
| W/V and V/V (n=10) |
0.95 (0.59) |
−0.93 (0.70) | −2.76 (0.91) | −0.44 (0.44) | −0.73 (0.42) | 0.15 (0.20) | ||
| Adj P-value | 0.3333 | 0.6340 | 0.9210 | 0.3467 | 0.2922 | 0.5513 | ||
| 4- year |
W/W (n=3) | 0.61 (0.69) |
0.11 (0.22) | 0.46 (1.23) | 0.50 (0.86) | 1.13 (0.92) | −0.18 (0.04) | |
| W/V and V/V (n=5) |
1.10 (0.75) |
1.31 (0.23) | 0.54 (1.10) | −0.41 (0.93) | −0.41 (1.00) | 0.28 (0.03) | ||
| Adj P-value | 0.5998 | 0.0196 | 0.9669 | 0.4511 | 0.2631 | 0.0651 | ||
| 5- year |
W/W (n=0) | n/a | n/a | n/a | n/a | n/a | n/a | |
| W/V and V/V (n=5) |
0.09 (0.63) |
0.16 (0.73) | −1.90 (1.74) | −0.10 (0.15) | −0.36 (0.35) | 0.25 (0.26) | ||
| Adj P-value | n/a | n/a | n/a | n/a | n/a | n/a |