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. Author manuscript; available in PMC: 2017 Dec 5.
Published in final edited form as: Adv Exp Med Biol. 2017;963:337–358. doi: 10.1007/978-3-319-50044-7_20

Figure 4. Scheme of p90RSK functional domains.

Figure 4

The N-terminus kinase belongs to the AGC group of kinases (i.e., protein kinase A [PKA] and protein kinase C [PKC]), while the C-terminus kinase belongs to the calcium/calmodulin-dependent kinase group. p90RSK is located downstream of the Raf-MEK-ERK1/2 signaling pathway (65), and ERK1/2 activates the C-terminus kinase of p90RSK, leading to full activation of the N-terminus kinase and subsequent substrate phosphorylation. However, the involvement of an ERK1/2-independent pathway and the role of fyn kinase in regulating ROS-induced p90RSK activation have also been suggested (66). Recently, we have reported that p90RSK is activated by d-flow, but not by s-flow (67). Reprinted and modified from Heo et al(Heo et al., 2016) with permission of the publisher.