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. Author manuscript; available in PMC: 2017 Dec 5.
Published in final edited form as: Adv Exp Med Biol. 2017;963:337–358. doi: 10.1007/978-3-319-50044-7_20

Figure 6. Post-translational regulation of mammalian DNA methytransferases.

Figure 6

DNMTs protein domain structure and SUMylation. A. DNMT1; DMAP1 domain, PCNA domain, nuclear localization signal domain (NLS), DNA replication foci-targeting domain, CXXC- zinc finger region, bromo-adjacent homology domains (BAH1 and BAH2), and catalytic domain. More than 10 SUMOylation sites throughout DNMT1 sequence were suggested. B. DNMT 3A and 3B; a proline-trytophan-proline domain (PWWP), an ATRX-DNMT3-DNMT3L-type zinc finger domain (ADD), and catalytic domain. SUMOylation of the N-terminal regulatory region including the PWWP domain was reported. Reprinted and modified from Heo et al(Heo et al., 2016) with permission of the publisher.