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. Author manuscript; available in PMC: 2017 Dec 5.
Published in final edited form as: Adv Exp Med Biol. 2017;963:337–358. doi: 10.1007/978-3-319-50044-7_20

Figure 8. SUMO1 modification of Dynamin Related Protein (DRP1) and mitochondrial fission.

Figure 8

The process of mitochondrial fission is regulated by the recruitment and oligomerization of the DRP1. SUMO1 modification of DRP1 increases DRP1 activity, which is regulated by a SUMO E3 ligase MAPL, and deconjugating enzymes include SENP5 (a SUMO protease). The crucial role of GTPase Opa1 and mitofusin has been reported, but the role of SUMOylation in this process remains unclear(Braschi and McBride, 2010).