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. Author manuscript; available in PMC: 2017 Dec 5.
Published in final edited form as: Adv Exp Med Biol. 2017;963:337–358. doi: 10.1007/978-3-319-50044-7_20

Figure 9. SUMOylation of dynaminrelated protein (Drp1) in regulating mitochondrial fission.

Figure 9

SENP5 was identified as SUMO deconjugases of DRP1 in Hela, Cos7, and cardiomyocytes. Silencing of SENP5 In COS-7 or HeLa cells SUMO1 modification of DRP1 is increased by the depletion of SENP5 and the E3 SUMO ligase mitochondrialanchored protein ligase (MAPL). SUMO1 modification of DRP1 enhances DRP1 binding to mitochondria, leading to mitochondrial fragmentation and cellular apoptosis. In contrast, in cardiomyocytes SENP5 inhibits SUMO2/3 modification of DRP1. De-SUMOylated DRP1 can bind to mitochondria, and subsequently induced mitochondrial fragmentation and apoptosis(Mendler et al., 2016).