Table II.
Clinical outcome in patients surviving beyond 12 months
| Patient follow-up (mo) | Infections cleared | Autoimmunity | Attending school/preschool | Significant ongoing treatments | Other problems |
|---|---|---|---|---|---|
| 1. 69 (after second transplantation) | HHV6 | Transient nephritis Thyroiditis |
Yes | Thyroxine | Enteropathy resolved Feeding problems Hypoparathyroidism |
| 2. 80 |
Clostridium difficile, RSV Adenovirus∗ Enterovirus, Varicella Parainfluenza 3 Norovirus, rhinovirus |
Transient colitis Chronic AIHA ITP |
Yes | Splenectomy Sirolimus Iron Chelation Immunoglobulin replacement |
Iron overload Hypoparathyroidism, GH deficiency Scoliosis |
| 3. M, 67 | RSV, parainfluenza 3 Metapneumovirus, EBV (primary) |
None | Yes | Azithromycin prophylaxis Tracheostomy–decannulated |
Chronic lung disease Recurrent respiratory tract infections |
| 4. M, 55 |
Rotavirus Parainfluenza 3 Metapneumovirus, RSV, influenza A |
Early transient AIHA | Yes | Azithromycin prophylaxis | Nephrocalcinosis Chronic lung disease Respiratory tract infections (mild) Enteropathy resolved |
| 5. M, 49 mo |
BCG, rotavirus Parainfluenza 3 |
None | Yes | Azithromycin prophylaxis | Hypoparathyroidism Chronic lung disease No respiratory tract infections Complex congenital heart–stable |
| 6. M, 46 | Norovirus | None | Yes | Immunoglobulin therapy Cleft lip/palate repair |
Hypoparathyroidism Enteropathy resolved Chronic lung disease Recurrent respiratory tract infections Hydrocephalus (shunted) |
| 8. M, 30 | Rhinovirus, RSV | Thyroiditis ITP, Neutropenia |
Yes | Gastrostomy feeding Thyroxine |
Hypoparathyroidism Feeding/gut motility problems Chronic secretory otitis media |
| 9. M, 25 | BCG, rotavirus, RSV | Early transient AIHA | No | On immunoglobulin therapy Thyroxine |
Hypoparathyroidism Hypothyroidism |
| 10. F, 23 | HHV6, adenovirus | ITP: Fatal at 23 mo after transplantation | No | On immunoglobulin therapy Thyroxine |
Hypoparathyroidism Hypothyroidism–resolved Fatal cerebral hemorrhage complicating ITP |
| 11. M, 21 |
Coronavirus, C difficile Campylobacter species |
Thyroiditis ITP Increased transaminase levels |
Yes | On immunoglobulin therapy Thyroxine |
Hypoparathyroidism |
Boldface type indicates an infection that was present before transplantation.
AIHA, Autoimmune hemolytic anemia; GH, growth hormone; ITP, immune thrombocytopenia; RSV, respiratory syncytial virus.
∗
1 × 105 copies/mL of blood.