. 2017 Oct 26;8(58):97822–97834. doi: 10.18632/oncotarget.22085

Table 1. Effect of P2X7R inhibitors on the body weight, PanINs multiplicity and PDAC in LSL-Kras^G12D/+ male mice.

	Agent	No. of mice	BW Grams Mean	PanIN1 Mean ± SE	PanIN2 Mean ± SE	PanIN3 Mean ± SE	Total PanINs Mean ± SE	% Normal Mean ± SE	% Ca spread Mean ± SE	Ca incidence	Pan WT Grams Mean
1	Control	26	38.5	208 ± 25	106 ± 11	25 ± 6	339 ± 14	8.1 ± 2.9	24.3 ± 6.1	50%	1.56
2	A438079 50 ppm	19	36.7	105 ± 27	58 ± 13	27 ± 12	190 ± 17	8.2 ± 3.7	52.7 ± 10.2	60%	1.34
3^*	A438079 100 ppm	17	38.7	173 ± 52	99 ± 29	34 ± 15	306 ± 32	3.2 ± 1.1	49.7 ± 13.9	61%	1.41
4	AZ10606120 50 ppm	17	37.4	168 ± 63	76 ± 22	27 ± 13	271 ± 33	12.5 ± 7.4	43.3 ± 15.1	63%	1.53
5^*	AZ10606120 100 ppm	13	37.7	292 ± 64	97 ± 17	39 ± 26	428 ± 36	10.2 ± 6	12 ± 10.4	33%	1.09

^*Mice in these groups were euthanized four weeks before actual termination schedule.

Table 1. Effect of P2X7R inhibitors on the body weight, PanINs multiplicity and PDAC in LSL-KrasG12D/+ male mice.