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. 2017 May 29;8(58):97835–97850. doi: 10.18632/oncotarget.18279

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Copyright: © 2017 Hu et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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RT-qPCR was performed to test the level of lncRNA-SVUGP2 (A) and some reported dysregulated lncRNAs (B–D) in three HCC samples. (E) lncRNA-SVUGP2 level was decreased in HCC tumor tissues compared with that in adjacent noncancerous tissues in 50 additional pairs of tissue samples. (F) Kaplan-Meier survival curve of 50 patients with high or low lncRNA-SVUGP2 level. Higher lncRNA-SVUGP2 level is correlated with better prognosis. (G) The result of ChIP-qPCR showing RNA Pol II occupancy on lncRNA-SVUGP2 promoter was decreased in HepG2 and Hep3B cell lines compared with that in normal hepatocyte, L02. (H) RNA Pol II occupancy on lncRNA-SVUGP2 promoter was also reduced in HCC tumor tissues compared to that in adjacent noncancerous tissues.