Table 4. The joint effect between RASA2, CADM1, HIF1AN polymorphisms and BMI on breast cancera.
| Genotype | BMI < 24 kg/m2 | BMI ≥ 24 kg/m2 | ||
|---|---|---|---|---|
| Case/Ctrl | OR (95% CI)b | Case/Ctrl | OR (95% CI)b | |
| RASA2 (rs16851483) | ||||
| G/G | 189/258 | 1.00 (referent) | 216/244 | 1.21 (0.91–1.62) |
| G/T | 128/189 | 1.00 (0.73–1.38) | 207/176 | 1.70 (1.26–2.30) |
| T/T | 22/29 | 1.33 (0.72–2.45) | 36/22 | 2.51 (1.38–4.56) |
| G/T+T/T | 150/218 | 1.04 (0.77–1.41) | 243/198 | 1.79 (1.34–2.40) |
| Interaction | Additive: | RERI = 0.98 (−0.10 to 2.05) | ||
| AP = 0.44 (0.26–0.62) | ||||
| S = 4.96 (1.54–15.91) | ||||
| Multiplicative: | ROR=1.77 (1.33–2.37) | |||
| CADM1 (rs12286929) | ||||
| G/A | 128/199 | 1.00 (referent) | 158/182 | 1.31 (0.93–1.82) |
| A/A | 185/249 | 1.13 (0.82–1.55) | 257/221 | 1.78 (1.31–2.43) |
| G/G | 23/34 | 1.07 (0.58–1.98) | 46/40 | 1.73 (1.03–2.92) |
| A/A+G/G | 208/283 | 1.12 (0.83–1.53) | 303/261 | 1.78 (1.32–2.40) |
| Interaction | Additive: | RERI = 1.19 (−0.28 to 2.65) | ||
| AP = 0.45 (0.25–0.65) | ||||
| S = 3.67 (2.26–5.94) | ||||
| Multiplicative: | ROR=1.77 (1.31–2.39) | |||
| HIF1AN (rs17094222) | ||||
| T/T | 148/221 | 1.00 (referent) | 197/207 | 1.33 (0.98–1.82) |
| T/C | 163/201 | 1.14 (0.83–1.57) | 205/180 | 1.61 (1.18–2.21) |
| C/C | 27/58 | 0.64 (0.37–1.10) | 58/56 | 1.52 (0.96–2.42) |
| T/C+C/C | 190/259 | 1.03 (0.76–1.39) | 263/236 | 1.59 (1.19–2.14) |
| Interaction | Additive: | RERI = 0.82 (−0.26 to 1.89) | ||
| AP = 0.37 (0.15–0.59) | ||||
| S = 3.22 (1.79–5.81) | ||||
| Multiplicative: | ROR = 1.58 (1.18–2.13) | |||
aMissing data were excluded from analysis. bAdjusted for age (continuous),education level, marital status, residence area, previous income (continuous), using of hormone drugs, moderate exercise (continuous), first-degree family history of breast cancer and menopausal status.