Skip to main content
. 2017 Sep 21;8(58):98298–98311. doi: 10.18632/oncotarget.21176

Figure 2. COMP-expressing cells form larger tumors in vivo.

Figure 2

The expression of COMP by DU145 cells was confirmed by western blot where COMP was present in monomeric, intermediate, and pentameric forms under non-reducing conditions, while migrating as a sharp 130 kDa band under reducing conditions (A). The cells were injected in the flank of nude mice and the tumor volume was monitored over time. Cells expressing COMP formed significantly larger tumors (B), and the weight of the animals remained stable throughout the experiment (C). The tumors were excised at the end of the experiment and immunostained for COMP (D). The data in B-C represent mean values ±SEM, and was compared by 2-way ANOVA with Bonferroni post-test. mCOMP, momomeric COMP; iCOMP, intermediate forms of COMP; pCOMP, pentameric COMP. The symbols * and *** stand for p <0.05, and p <0.001.