Table 2. Cluster differentiation genes that are downregulated in MMC compared with normal BMPC.
| Probeset | Gene | Ratio | FDR | Affymetrix description |
|---|---|---|---|---|
| 215049_x_at | CD163 | 0.16 | 0.00 | CD163 molecule |
| 206398_s_at | CD19 | 0.32 | 0.00 | CD19 molecule |
| 216379_x_at | CD24 | 0.40 | 0.00 | CD24 molecule |
| 228766_at | CD36 | 0.22 | 0.00 | CD36 molecule (thrombospondin receptor) |
| 34210_at | CD52 | 0.28 | 0.00 | CD52 molecule |
| 206680_at | CD5L | 0.25 | 0.00 | CD5 molecule-like |
| 203507_at | CD68 | 0.27 | 0.00 | CD68 molecule /// small nucleolar RNA, H/ACA box 67 |
| 205049_s_at | CD79a | 0.37 | 0.00 | CD79a molecule, immunoglobulin-associated alpha |
| 207176_s_at | CD80 | 0.47 | 0.00 | CD80 molecule |
| 200675_at | CD81 | 0.29 | 0.00 | CD81 molecule |
| 203904_x_at | CD82 | 0.23 | 0.00 | CD82 molecule |
| 205988_at | CD84 | 0.43 | 0.00 | CD84 molecule |
| 201029_s_at | CD99 | 0.37 | 0.00 | CD99 molecule |
| 204007_at | FCGR3b | 0.42 | 0.00 | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) |
| 213475_s_at | ITGAL | 0.47 | 0.00 | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
| 206150_at | TNFRSF7 | 0.25 | 0.00 | CD27 molecule |
Gene expression was profiled in MMC samples from the HM cohort (n=206 patients with MM) and BMPC samples (healthy controls; n=7) using Affymetrix U133 plus 2.0 microarrays. Genes that are significantly differentially expressed were identified using SAM supervised unpaired analysis with a 5% false discovery rate.