Figure 2. Sema3E deficient mice show enhanced AHR upon chronic HDM exposure.

Sema3e^−/− mice or WT littermates exposed to HDM for 7 weeks underwent tracheotomy accompanied by methacholine challenge to measure AHR parameters including airway resistance (A and D), tissue resistance (B and E), and tissue elastance (C and F). The data represent two independent experiments on age and sex-matched mice. (n = 5-6 per group, ^*P<0.05, ^**P<0.01. and ^***P<0.001).