Figure 6. Intranasal Sema3E treatment attenuates chronic allergic asthma deficits upon HDM re-exposure.

Mice were exposed with HDM for 7 weeks then treated with Sema3-Fc or Fc-Ig control then exposed to HDM for one more week (A) Intranasal administration of Sema3E protects mice against HDM-induced airway resistance after re-exposure with HDM (B). Sema3E treatment also reduced total (C) and granulocytic (D) recruitment of inflammatory cells into the airways. Pulmonary inflammation and mucus hyper-secretion were decreased upon Sema3E treatment (E). Decreased secretion of Th2 and Th17 cytokines by Sema3E was sustained upon HDM re-exposure. (F) E: eosinophil, N: neutrophil, M: macrophage, L: lymphocyte. (n=4, ^*P<0.05, P<0.01 and ^***P<0.001).