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One compartment model population pharmacokinetic parameter estimates.
| Parameter | Estimate | R.S.E. (%) |
|---|---|---|
| Ka (h−1) | 10.0 (fixed) | n.a. |
| Vd/F (L) | 29.1 | 15 |
| CL/F (L/h) | 6.29 | 9 |
| ω-BSV | ||
| Vd/F | 0.225 | 70 |
| CL/F | 0.0478 | 565 |
| σ-RUV | 0.380 | 17 |
Ka – Absorption rate constant; Vd/F – apparent volume of distribution; CL/F – apparent clearance; BSV- between subject variability; RUV- residual unexplained variability; R.S.E. – relative standard error.
