Table 3.
Overrepresented gene ontology (GO) terms from g:Profiler (q-value < 0.05) for the 19 outlier loci from tests for both selection and GEA. Associated genes shows which ensemble gene homologs from Table 2 are associated with each overrepresented term.
| Description | Annotation ID | P-value | Associated Genes |
|---|---|---|---|
| Negative regulation of protein kinase B signaling | GO:0051898 | 0.05 | ENSMUSG00000024066, ENSMUSG00000041161 |
| Cytochrome c oxidase, mitochondrial | CORUM:538 | 0.05 | ENSMUSG00000064358 |
| Ocrl-Cdc42 complex | CORUM:975 | 0.00914 | ENSMUSG00000001173 |
| Glyoxylate and dicarboxylate metabolism | KEGG:00630 | 0.0355 | ENSMUSG00000035637 |
| Homologous recombination | KEGG:03440 | 0.0512 | ENSMUSG00000021287 |
| Pyruvate metabolism | KEGG:00620 | 0.0464 | ENSMUSG00000035637 |
| Oxidative phosphorylation | KEGG:00190 | 0.00791 | ENSMUSG00000002379, ENSMUSG00000064358 |
| Alzheimer’s disease | KEGG:05010 | 0.0133 | ENSMUSG00000002379, ENSMUSG00000064358 |
| Huntington’s disease | KEGG:05016 | 0.0158 | ENSMUSG00000002379, ENSMUSG00000064358 |
| Non-alcoholic fatty liver disease (NAFLD) | KEGG:04932 | 0.0101 | ENSMUSG00000002379, ENSMUSG00000064358 |
| Glycine, serine and threonine metabolism | KEGG:00260 | 0.05 | ENSMUSG00000035637 |
| Metabolic pathways | KEGG:01100 | 0.0029 | ENSMUSG00000001173, ENSMUSG00000002379, ENSMUSG00000024066, ENSMUSG00000035637, ENSMUSG00000064358 |
| Parkinson’s disease | KEGG:05012 | 0.00899 | ENSMUSG00000002379, ENSMUSG00000064358 |
| Autophagy - other | KEGG:04136 | 0.0404 | ENSMUSG00000106907 |
| Caffeine metabolism | KEGG:00232 | 0.00742 | ENSMUSG00000024066 |