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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Prog Biophys Mol Biol. 2017 Aug 26;130(Pt B):404–417. doi: 10.1016/j.pbiomolbio.2017.08.008

Fig. 1.

Fig. 1

A) Schematic image of stretch-induced MEF mechanisms, SACs and stretch induced calcium release, modelled in the cell models. SACs occur at the cell membrane while calcium release from myofilaments occurs intracellularly. In this schematic representation the L-type calcium channel (L-type) is the high-voltage dihydropyridine channel which is responsible for ECC in cardiac cells, the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) is located next to the SR in myocytes and transfers calcium from the cytosol in the SR under ATP hydrolysis during relaxation, and ryanodine receptors (RyRs) are the cellular mediator of calcium-induced calcium release (CICR).