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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Thromb Haemost. 2017 Oct 27;15(12):2396–2407. doi: 10.1111/jth.13863

Figure 1. Thrombin but not ADP or U46619 blocks subsequent platelet GPVI activation by convulxin.

Figure 1

(A) Platelet activation by thrombin for 480 seconds causes a significant reduction in subsequent convulxin-induced calcium response. This effect was apparent for doses of thrombin (1 – 10 nM) treatment of diluted (12%), apixaban-treated PRP. (B) Platelet activation by ADP does not significantly attenuate subsequent convulxin-induced calcium response. (C) Platelet activation by the thromboxane analog, U46619, did not significantly attenuate subsequent convulxin-induced calcium response. (C, convulxin; T, thrombin; A, ADP; U, U46619).