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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Thromb Haemost. 2017 Oct 27;15(12):2396–2407. doi: 10.1111/jth.13863

Figure 5. Inhibition of fibrin polymerization with GPRP prevents thrombin-induced convulxin-insensitivity.

Figure 5

(A) The thrombin-induced attenuation of platelet calcium GPVI signaling was not observed when GPRP was present. (B) Because platelet activation by ADP does not cause fibrinogen to polymerize into fibrin, GPRP has no effect on subsequent convulxin response. (C) Following thrombin stimulation of platelets, fibrin results in a sustained calcium mobilization that returned to unstimulated levels in the presence of GPRP.