Table 4.

Multivariable analysis of association between fluid overload at ECMO initiation and peak fluid overload, with ECMO and hospital mortality.

Outcome	FO at ECMO Initiation*	Pediatric**	ECMO Mode (Other)***	ECMO Mode VV ***	Support Type: Cardiac****	Support Type: ECPR****	Non-Renal Patient Complications	pH at initiation	AKI
ECMO Mortality	1.04 (0.97,1.11)	0.93 (0.62,1.39)	0.65 (0.13,3.34)	0.3 (0.16,0.56) ##	1.27 (0.76,2.14)	1.47 (0.86,2.51)	6.07 (1.99,18.50) ##	0.12 (0.04,0.35) ##	2.4 (1.29,4.46) #
Hospital Mortality	1.13 (1.05,1.22) ##	0.52 (0.36,0.76) ##	0.21 (0.04,1.06)	0.26 (0.16,0.43) ##	1.27(0.79,2.05)	1.22(0.74,2.01)	6.27 (2.78,14.14) ##	0.31 (0.12,0.79) #	2.6 (1.59,4.27) ##
	Peak FO on ECMO*	Pediatric**	ECMO Mode (Other)***	ECMO Mode VV ***	Support Type: Cardiac****	Support Type: ECPR****	Non-Renal Patient Complications	pH at initiation	AKI
ECMO Mortality	1.09 (1.04,1.15) ##	0.99 (0.66,1.49)	0.7 (0.13, 3.68)	0.32 (0.17, 0.6) ##	1.42 (0.84,2.42)	1.7 (0.99,2.94)	5.98 (1.89,18.88) ##	0.13 (0.05,0.38) ##	2.24 (1.2,4.2) #
Hospital Mortality	1.18 (1.12,1.24) ##	0.59 (0.4,0.86) #	0.23 (0.04,1.25)	0.27 (0.16,0.45) ##	1.55 (0.94,2.53)	1.57 (0.93, 2.63)	5.8 (2.45,13.71) ##	0.38 (0.14,1.00)	2.47 (1.48,4.11) ##

All models adjusted for centre in addition; all data presented as Odds Ratio (95% Confidence interval)

^*Examines per 10% rise in FO

^**Reference neonates;

^***Reference VA ECMO,

^****Reference Respiratory

^#p<0.05;

^##p<0.005