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. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: BJU Int. 2017 Jun 29;120(4):576–583. doi: 10.1111/bju.13924

Fig. 2 — Effects of anti-VEGF pre-treatment on cyclophosphamide (CYP)-induced pelvic pain. A: Effect of CYP (150 mg/kg i.p.) on referred pelvic allodynia assessed using von Frey filaments (n=6). Note that the saline injected prior to CYP was used as the control arm of anti-VEGF pre-treatment. B: The area under the curve (AUC) of A. C: Effect of anti-VEGF pre-treatment (10 mg/kg i.p.) followed by CYP (150 mg/kg i.p.) on pelvic nociceptive response (n=7). D: The area under the curve (AUC) of C. E: Comparison of AUC between anti-VEGF and saline pre-treatment groups at various time points. Anti-VEGF pre-treatment was effective in reducing pelvic pain 48 and 96 hours after CYP compared to saline pre-treatment. *p<0.05, **p<0.005, ***p<0.001.

Fig. 2 — Effects of anti-VEGF pre-treatment on cyclophosphamide (CYP)-induced pelvic pain. A: Effect of CYP (150 mg/kg i.p.) on referred pelvic allodynia assessed using von Frey filaments (n=6). Note that the saline injected prior to CYP was used as the control arm of anti-VEGF pre-treatment. B: The area under the curve (AUC) of A. C: Effect of anti-VEGF pre-treatment (10 mg/kg i.p.) followed by CYP (150 mg/kg i.p.) on pelvic nociceptive response (n=7). D: The area under the curve (AUC) of C. E: Comparison of AUC between anti-VEGF and saline pre-treatment groups at various time points. Anti-VEGF pre-treatment was effective in reducing pelvic pain 48 and 96 hours after CYP compared to saline pre-treatment. *p<0.05, **p<0.005, ***p<0.001.