Table 3.
Summary of all nominally significant associations with Lewy body counts
| Minor allele not present | Minor allele present | Association with LB count in the given brain region | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Variant | Nearest gene | Chr. | Position | MA | MAF | Cortical region | Mean (Q1, Q3) LB count | N | Mean (Q1, Q3) LB count | N | Multiplicative increase (95% CI) | P-value |
| rs11724635 | BST1 | 4 | 15737101 | C | 43.3% | Superior temporal | 8.5 (3, 12) | 164 | 10.4 (3, 16) | 360 | 1.19 (1.01, 1.39) | 0.033 |
| rs11724635 | BST1 | 4 | 15737101 | C | 43.3% | Inferior parietal | 2.7 (0, 4) | 165 | 3.7 (1, 5) | 359 | 1.27 (1.03, 1.57) | 0.028 |
| rs11724635 | BST1 | 4 | 15737101 | C | 43.3% | Cingulate | 8.5 (4, 12) | 162 | 10.5 (4, 16) | 358 | 1.20 (1.04, 1.38) | 0.010 |
| rs3910105 | SNCA | 4 | 89761420 | C | 49.1% | Superior temporal | 11.1 (4, 16) | 136 | 9.3 (3, 14) | 403 | 0.83 (0.71, 0.97) | 0.023 |
| rs76904798 | LRRK2 | 12 | 40614434 | T | 13.5% | Inferior parietal | 3.6 (1, 5) | 406 | 2.7 (0, 4) | 138 | 0.77 (0.62, 0.96) | 0.021 |
| rs14235 | BCKDK/STX1B | 16 | 31121793 | A | 41.5% | Middle frontal | 3.7 (1, 5) | 191 | 4.8 (1, 7) | 355 | 1.28 (1.06, 1.54) | 0.011 |
| rs14235 | BCKDK/STX1B | 16 | 31121793 | A | 41.5% | Superior temporal | 8.8 (2, 14) | 190 | 10.3 (4, 15) | 355 | 1.17 (1.01, 1.35) | 0.041 |
| rs14235 | BCKDK/STX1B | 16 | 31121793 | A | 41.5% | Inferior parietal | 2.7 (0, 4) | 191 | 3.8 (1, 5) | 354 | 1.36 (1.11, 1.65) | 0.0026 |
| rs17649553 | MAPT | 17 | 43994648 | A | 22.8% | Middle frontal | 4.0 (1, 6) | 331 | 5.0 (1, 7) | 213 | 1.25 (1.04, 1.49) | 0.016 |
| rs17649553 | MAPT | 17 | 43994648 | A | 22.8% | Inferior parietal | 3.1 (1, 4) | 330 | 3.8 (1, 6) | 213 | 1.24 (1.02, 1.50) | 0.029 |
Chr=chromosome; MA=minor allele; MAF=minor allele frequency; Q1=first quartile (i.e. 25th percentile); Q3=third quartile (i.e. 75th percentile); CI=confidence interval; LB=Lewy body. Multiplicative increases, 95% CIs, and p-values result from negative binomial regression models adjusted for age at death and sex. Multiplicative increases are interpreted as the multiplicative increase in mean Lewy body count in the given brain region corresponding to presence of the minor allele of the given variant. After applying a Bonferroni correction for multiple testing, p-values of 0.0017 or lower are considered as statistically significant. Nominally significant associations were those with a p-value of 0.05 or lower.