Table 6.

Summary of the univariate and multivariate findings in our cohort of active professional fighters and healthy controls.

Statistical method used	Regions found to be significant	Associated with neuropyschological assessments or exposure to fighting
Univariate
■Structural MRI
a.Global gray matter density (GMD)	No difference	Positively associated with psychomotor speed in active professional fighters
b.Global white matter density (WMD)	No difference	Negatively associated with reaction time in active professional fighters
c.GMD (voxelwise)	No difference	No association
d.WMD (voxelwise)	Cluster involving bilateral pons, hippocampus, and thalamus	Negatively associated with reaction time in active professional fighters
■Cerebral blood flow (CBF)
a. Global Partial volume corrected (PV-Corr)	No difference	No association
b. Global Non-partial volume corrected (NonPV-Corr)	No difference	No association
c. PV-Corr (voxelwise)	Cluster in right inferior temporal lobe	Positively associated with verbal memory and negatively associated with reaction time in healthy controls
d. NonPV-Corr (voxelwise)	1. Cluster in right inferior temporal lobe 2. Cluster in right fusiform gyrus and cerebellum	Positively associated with verbal memory and negatively associated with psychomotor speed and reaction time in healthy controls No association
Multivariate voxelwise analysis
■GMD, WMD, and CBF-PV-Corr	1.Cluster in right precuneus	Positively associated with psychomotor speed in healthy controls
	2.Cluster in right hippocampus	No association
	3.Cluster in left hippocampus	No association
	4.Cluster in bilateral thalamus	Positively associated with number of professional fights
■GMD, WMD, and CBF-NonPV-Corr	1.Cluster in right precuneus	Positively associated with psychomotor speed in healthy controls
	2.Cluster in right olfactory cortex	No association
	3.Cluster in right hippocampus	No association
	4.Cluster in left hippocampus	No association
	5.Cluster in bilateral thalamus	Positively associated with number of professional fights