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. 2017 Dec 1;7:283. doi: 10.3389/fonc.2017.00283

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Copyright © 2017 Martínez-Aranda, Hernández, Moreno, Baixeras, Cuadras, Urruticoechea, Gil-Gil, Vidal, Andreu, Seguí, Ballester, Castella and Sierra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain metastasis-free survival (BrMFS) in breast cancer patients according to expression of FN14 and GRP94 biomarkers. Comparisons between Luminal (A) and non-Luminal (B) groups, according to FN14 positivity in primary tumors revealed a shortened BrMFS that was statistically significant in the Luminal group (HR = 8.25; 95% CI: 2.77–24.61; p = 0.00015) but not in the non-Luminal one (HR = 1.74; 95% CI: 0.87–3.47; p = 0.11). With regard to GRP94 positivity, shortened BrMFS in Luminal (C) and non-Luminal (D) groups was not statistically significant (HR = 3.58; 95% CI: 0.98–13.11; p = 0.054 and HR = 1.22; 95% CI: 0.64–2.32; p = 0.55, respectively).