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. 2017 Dec 1;7:494. doi: 10.3389/fcimb.2017.00494

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Copyright © 2017 Thangamani, Hermance, Santos, Slovak, Heinze, Widen and Kazimirova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in gene expression related to the inflammatory response after 1 and 3 h of TBEV-infected Ixodes ricinus tick feeding. Temporal changes in gene expression data were analyzed by IPA software. Genes predicted to be directly involved in the “Inflammatory Response” were plotted to show temporal changes in gene expression for the following comparisons: TBEV-infected tick feeding loci at 1 h vs. uninfected tick feeding loci at 1 h, TBEV-infected tick feeding loci at 3 h vs. uninfected tick feeding loci at 3 h, TBEV-infected tick feeding loci at 3 h vs. TBEV-infected tick feeding loci at 1 h. Genes with significant modulation in expression (p ≤ 0.05) are marked with an asterisk.