FIGURE 4.

Effect of 100 nM CGS 21680 on A375 and MRMT-1 cell viability (48 h) as well as in A549 (24 h) and antagonism by 100 nM ZM 241385 and 10 nM TP455 by DELFIA Cell Proliferation Kit. Solutions were made up in DMSO and then diluted in cell culture medium (0.1 max 0.2% of DMSO). An equal amount of DMSO was used in control cells (CTR) incubated for 24 h in case of A549 and 48 h in case of A375 and MRMT-1. ^∗P < 0.01 compared with CTR. Means ± SE values from four experiments are shown. Analysis was by one way ANOVA, followed by Dunnett’s test.