Table 1.

Inhibition of [³H]ZM241385 binding (Ki nM) by adenosine receptor agonists and antagonists in human A375 melanoma, A549 lung carcinoma, and rat MRMT-1 breast carcinoma membranes.

Compounds	A375 Ki (nM)	A549 Ki (nM)	MRMT-1 Ki (nM)
Agonists
CGS21680	15 1	16 2	14 1
NECA	6.65 0.52	12 1	9.33 0.95
Cl-IB-MECA	694 75	710 89	500 64
R-PIA	725 78	670 75	423 52
Antagonists
SCH58261	2.82 0.32	3.15 0.34	3.26 0.43
ZM241385	2.23 0.26	2.33 0.24	2.47 0.23
CGS15943	1.45 0.18	1.66 0.20	2.15 0.34
TP455	0.0058 0.0002	0.0053 0.0003	0.0061 0.0003

The data are expressed as mean ± SE.