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. 2017 Dec 5;7:16914. doi: 10.1038/s41598-017-17193-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The pericyte-myofibroblast transition and core fucosylation were increased in patients with different Oxford classifications of IgAN. (a) Representative images of Masson’s trichrome-stained and PAS-stained sections from patients with different Oxford T classifications of IgAN. (b) Representative images of PDGFRβ (green) and CD31 (red) staining; white arrows indicate pericytes. Quantification is shown in the lower panel. (c) Representative images of PDGFRβ (green) and α-SMA (red) staining. Quantification is shown in the lower panel. (d) Representative images of dual staining for PDGFRβ (green) and FUT8 (red) and dual staining for LCA (green) and PDGFRβ (red). Quantification is shown in the lower panel. (e) Spearman’s correlation coefficients were used to examine the differences in the fluorescence intensity of immunostaining for PDGFRβ, α-SMA, FUT8, and LCA in patients with different Oxford T classifications of IgAN. r, Spearman’s correlation coefficient; r1, PDGFRβ; r2, α-SMA; r3, FUT8; r4, LCA. Scale bar, 50 μm. *P < 0.01, ^† P < 0.01. * and ^† indicate the comparison of the T1 or T2 group with the T0 group.