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. 2017 Dec 5;7:16914. doi: 10.1038/s41598-017-17193-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Core fucosylation regulates the pericyte-myofibroblast transition through both the TGFβ/Smad2/3 and PDGF/ERK1/2 pathways in vitro. (a) TGFβR1 and PDGFRβ levels in total cell lysates were assessed using Western blot analyses. Lectin blot analysis of the immunoprecipitated TGFβR1 and PDGFRβ proteins. TGFβR1 and PDGFRβ were immunoprecipitated from whole cell lysates with anti-TGFβR1 and anti-PDGFRβ antibodies, respectively. The blots were probed with LCA. Representative data are shown. Quantification is shown in the lower panel. (b) Smad2/3, p-Smad2/3, ERK1/2, and p-ERK1/2 levels were assessed using Western blot analyses. Total cell lysates were subjected to immunoblotting. Representative data are shown. Quantification is shown in the lower panel. *P < 0.01, ^# P < 0.01. * and ^† indicate the comparison of the control group with the TGFβ1 group; ^# indicates the comparison of the FUT8 knockdown group with the TGFβ1 group.