Table 1.

The macrophage response/role during zebrafish infection.

Microbe			Macrophage response/role	Reference
Bacteria	Mycobacteria	Mycobacterium marinum	Recruitment, phagocytosis, intracellular niche for bacteria, accumulation in granuloma-like structures, restriction and promotion of bacterial dissemination	(42, 45, 47, 48, 51, 52)
		Mycobacterium leprae	Recruitment, phagocytosis, RNS production causing axonal damage	(58)
	Gram-positive	Listeria monocytogenes	Recruitment, phagocytosis, intracytosolic niche for bacteria, restriction of bacterial dissemination	(53, 65, 66)
		Staphylococcus aureus	Recruitment, phagocytosis, restriction of bacterial proliferation in blood	(67, 68)
	Gram-negative	Burkholderia cenocepacia	Recruitment, phagocytosis, intracellular niche for bacteria, source of inflammatory response	(70, 71)
		Salmonella Typhimurium	Recruitment, phagocytosis, intracellular niche for bacteria, IRG1-dependent ROS production, stimulates emergency granulopoiesis by G-CSF secretion	(72–74)
		Shigella flexneri	Recruitment, phagocytosis, scavenging of bacteria prior to neutrophil control	(54, 79, 80)
Fungi		Apergillus fumigatus	Recruitment, phagocytosis, production of TNFα for neutrophil recruitment, lateral transfer of Aspergillus from necroptotic to naive macrophages	(83, 84, 86, 87)
		Candida albicans	Recruitment, phagocytosis, restriction of spore germination, rare fungal killing	(88, 89, 91)
		Cryptococcus neoformans	Recruitment, phagocytosis, expulsion of Cryptococcus by vomocytosis	(55, 93)
		Mucor circelloides	Recruitment, phagocytosis, accumulation around viable spores in granuloma-like structures	(56)