Table 3.
Univariate and multivariate Cox-regression analyses of different laboratory and clinical markers for the prediction of long-term survival.
| Parameter | Univariate Cox-regression | Multivariate Cox-regression | ||
|---|---|---|---|---|
| p-value | Hazard-Ratio (95% CI) | p-value | Hazard-Ratio (95% CI) | |
| CEA | <0.001*** | 1.046 (1.026–1.067) | 0.035* | 1.030 (1.002–1.058) |
| CA19-9 | 0.075 | 1.000 (1.000–1.000) | ||
| AFP | 0.287 | 0.966 (0.907–1.029) | ||
| CRP | <0.001*** | 1.010 (1.006–1.014) | 0.219 | 1.008 (0.995–1.021) |
| WBC | 0.064 | 1.059 (0.997–1.126) | ||
| Sodium | 0.026* | 0.950 (0.907–0.994) | 0.872 | 1.011 (0.882–1.159) |
| Potassium | 0.797 | 0.942 (0.597–1.487) | ||
| Calcium | 0.381 | 1.345 (0.693–2.612) | ||
| Haemoglobin | 0.009** | 0.825 (0.715–0.953) | 0.475 | 0.896 (0.663–1.211) |
| Thrombocytes | 0.763 | 1.000 (0.998–1.001) | ||
| AST | 0.934 | 1.000 (0.999–1.001) | ||
| ALT | 0.624 | 0.999 (0.997–1.002) | ||
| Bilirubin | 0.269 | 1.030 (0.977–1.085) | ||
| GGT | 0.073 | 1.000 (1.000–1.001) | ||
| ALP | 0.048* | 1.001 (1.000–1.002) | 0.947 | 1.000 (0.997–1.003) |
| Creatinine | 0.693 | 1.169 (0.539–2.533) | ||
| Age | 0.929 | 0.999 (0.979–1.020) | ||
| BMI | 0.198 | 1.030 (0.958–1.077) | ||
| Sex | 0.395 | 1.203 (0.786–1.843) | ||
| T stage (T1/2 vs. T3/4) | 0.002** | 2.042 (1.290–3.230) | 0.047* | 2.742 (1.015–7.404) |
| N stage | <0.001*** | 2.651 (1.628–4.317) | 0.769 | 1.177 (0.396–3.501) |
| M stage | <0.001*** | 2.963 (1.801–4.876) | 0.009* | 4.865 (1.472–16.075) |
WBC: white blood cell count, CRP: C-reactive protein, AST: aspartate transaminase, ALT: alanine transaminase, GGT: γ-Glutamyl transpeptidase, ALP: alkaline phosphatase, CEA: carcinoembryonic antigen, CA 19-9: carbohydrate-Antigen 19-9, AFP: Alpha-fetoprotein.