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. 2017 Dec 5;7:16993. doi: 10.1038/s41598-017-17027-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The discriminatory region of infrared absorbance spectra. (a) Average normalized ATR-FTIR spectra of serum samples extracted from EL4-lymphoma (n = 8), B16-melanoma (n = 8) mouse models in wild types and corresponding control types (n = 15). The inset (i) shows B16-melanoma mouse with tumor size approximately 1000 mm³ (day 18). Increase in volume of the tumor from the day 9 to day 18 of tumor inoculation in B16-melanoma mouse is as in inset (ii). Similar to the B16 mouse, elevation of tumor size is also monitored in EL4-lymphoma. The serum sample is extracted for both types of mice when tumor size becomes bigger than 1000 mm³. (b) Student’s t-test (two-tailed unequal variance) p-values of absorbance. Discriminatory region for lymphoma with higher significance (p < 0.05) are amide I of protein, amide II of protein, C-H bends of CH₃/CH₂ groups in α- and β- anomers, asymmetric phosphate I, and carbohydrates with predominant contributions nucleic acids (DNA/RNA via PO₂ ⁻ stretches). Discriminatory regions of melanoma are amide I and carbohydrates with predominant contributions of nucleic acids.