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. 2017 Dec 5;7:16983. doi: 10.1038/s41598-017-17289-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of T-5224 on human NP cells treated with IL-1β. (a) Quantification of c-Fos mRNA in human nucleus pulposus (NP) cells 24 h after stimulation with or without IL-1β. (b) Western blot analysis of c-Fos expression. (c) Immunofluorescence staining for human NP cells 2 h after the stimulation with or without IL-1β. Scale bars = 50 μm. (d) Expression of genes encoding proteins involved in catabolism, and inflammation in human NP cells (n = 3) 24 h after stimulation with recombinant IL-1β with or without T-5224. Error bars denote the mean ± SD. *P < 0.05 and **P < 0.01 (Tukey–Kramer post-hoc test). (e) Immunofluorescence staining for IL-1β-induced human NP cells 24 h after treatment with T-5224 (60 μM). Scale bars = 50 μm.