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. 2017 Dec 5;7:17014. doi: 10.1038/s41598-017-17147-x

Figure 2.

Figure 2

Synergy is demonstrated with NSC319726 and triazoles or caspofungin. (A) Drop plate assays are shown using NSC319726 alone (1 µg/mL), fluconazole alone (16 µg/mL), or NSC319726 in combination with fluconazole (FL) (16 µg/mL) (top to bottom panels). The combination of both drugs had a greater inhibition than either used alone. E-test assays were also performed with: (B) fluconazole (YPD only, far left) and NSC319726 at 1 μg (center) or 4 μg/ml; (C) itraconazole (IT) and NSC319726 (1 μg/mL); (D) or NSC319726 and voriconazole (VO), and (E) NSC319726 and caspofungin (CS) (0–4 μg/mL). Synergy is demonstrated for each combination, although more compound was needed to see maximum synergy with CS (4 μg/ml).