Table III.
Group | miR-140-3p | miR-140-5p |
---|---|---|
2-ΔΔCT | 2-ΔΔCT | |
Control | 1.07 (0.43; 0.59 to 1.972) | 1.08 (0.47; 0.624 to 1.879) |
GA | 0.82 (0.24; 0.529 to 1.214) | 0.85 (0.25; 0.48 to 1.206) |
RA | 0.86 (0.39; 0.308 to 1.464) | 0.8 (0.33; 0.382 to 1.24) |
Mild OA | 0.274 (0.13; 0.086 to 0.54)* | 0.36 (0.275; 0.14 to 1)† |
Moderate OA | 0.132 (0.086; 0.021 to 0.299)* | 0.173 (0.102; 0.09 to 0.356)‡ |
Severe OA | 0.031 (0.019; 0.008 to 0.08)* | 0.036 (0.031; 0.013 to 0.117)* |
Significant difference in the marked group compared with the other groups
Significant difference in the marked group compared with the control, GA, RA, and severe OA groups
Significant difference in the marked group compared with the control, GA, RA, and severe OA groups, p < 0.05
ΔΔCT = [(CTmiR-140-3p/5p - CTU6)group - (CTmiR-140-3p/5p - CTU6)control], 2-ΔΔCT = log transformed ΔΔCT, the fold change in miR-140-3p or miR-140-5p expression normalised to U6 and relative to control
CT, threshold cycle; GA, arthritis due to gout; RA, rheumatoid arthritis; OA, osteoarthritis