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. 2017 Aug 7;36(48):6701–6711. doi: 10.1038/onc.2017.267

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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LSD1 inhibition represses mTORC1 activity. (a) Protein extract from Tet-21/N treated with 1 mM TCP or vehicle (Ctrl) for 24 h were analyzed for the signaling activation using the PathScan antibody arrays. Graph shows the pixel density ratio of signaling molecule dots. Values represent the means of two independent experiments (± s.d.). (b) Western blotting of protein extracts from Tet-21/N cells treated for 0, 12 or 24 h with TCP or SP2509 (1 μM). (c) Tet-21/N cells were transfected with siRNA against LSD1 at different concentrations, or scramble (0). Cells were collected 48h after transfection. (d) Western blotting of protein extracts from SH-SY5Y cells treated for 24 h with TCP using the indicated antibodies. Actinin was probed as loading control.