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. 2017 Aug 7;36(48):6701–6711. doi: 10.1038/onc.2017.267

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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LSD1 regulates autophagy through SESN2 expression. (a) SH-SY5Ys were transfected with a SESN2 expression plasmid or empty vector, and protein extracts were prepared and stained with indicated antibody. (b) Localization of TFEB was analyzed in cells treated as described in A by immunostaining with TFEB antibody. (c) SH-SY5Y cells were transfected with siRNA against SESN2 or scramble. Twenty-four hours after transfection, cells were treated with TCP or vehicle for 24 h. Actinin was probed as loading control. Graphs show quantitative analysis of western blot experiments. A mean value±s.d. of four independent experiments is shown (*P<0.05; **P<0.005). (d) SH-SY5Y treated as described in c were fixed and stained with anti-TFEB and DAPI. Histograms show the percentage of TFEB nuclear translocation (mean±s.d., n=200 cells). *P<0.0001. DAPI, 4',6-diamino-2-phenylindole.