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. 2017 Nov 8;6(11):e100. doi: 10.1038/emi.2017.88

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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HBV nucleotide acid (nt1–3215) complexity values for C01, C02 and C03. The colored bars indicate the complexity of 5-bp nucleotides calculated by two methods for the full-length HBV genome (blue bars represent TGS and red bars represent CBS). Samples C01, C02 and C03 were presented from outer track to inner track, respectively. Theoretical values of each sample were indicated with black lines. clone-based sequencing, CBS; hepatitis B virus, HBV; third-generation sequencing, TGS.