Figure 2.

Tail infections in athymic HSD: NU mice were more vigorous than those in athymic NU/J mice. Hsd: NU (N = 5) and NU/J (N = 4) mice were infected on the tails with MmuPV1. Lesions became visible around week two post-infection in both mouse strains. However, lesions on Hsd: NU mice (Left) persisted and became significantly larger than those on NU/J nude mice by week seven post-infection (Right). The lesions on NU/J nude mice remained small and did not grow to significant size by week nineteen post-infection. One of the four NU/J nude mice did not develop any lesion at the tail site. Similar results were found at the muzzle sites in these two immunodeficient mouse strains.