TABLE 3.
Ranking of PA14 mutant PCF and BCF activities against A. fumigatus strain 10AF preformed biofilma
| Rank | Mutation(s) tested on: |
|
|---|---|---|
| Agar-PCF | Agar-BCF | |
| 1 | pvdD | pvdD |
| 2 | pvdD pchE | pvdD pchE |
| 3 | lasR | lasR rhlR |
| 4 | rsmA | lasR |
| 5 | lasR rhlR | |
a
All assays started from Aspergillus hyphae. The readout in both assays was XTT conversion. Ranking from 1 to n represents the highest to lowest loss of antifungal activity. Ranking was performed as described in Materials and Methods. Only isolates statistically significantly different from the parent strain are listed.