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. 2017 Dec 5;7:16955. doi: 10.1038/s41598-017-17176-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Flow diagram of the study. Fifty-seven patients were diagnosed with initial distant metastasis (DM). Patients were classified according to site of distant metastasis. Diagnoses were 31 with lung metastasis, 17 with bone metastasis, and 9 with combined lung/bone metastasis. Lung metastasis were subdivided into micronodular and macronodular. Bone metastasis were subdivided into solitary and multiple.