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. 2017 Dec 5;8:1858. doi: 10.1038/s41467-017-01851-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Body weight changes and fat accumulation in sham and ovx rats with or without treatment. Changes in body weight (a, b) and percentage fat accumulations (c) in ovx rats implanted with either hormone pellets (a, c) or ovarian constructs (b, c) compared to ovary-intact rats and ovx control groups. DXA scans for lean body mass with each formulation (d). Each data point represents the mean ± SEM of 10 animals (biological replicates) with each data point as a single technical experiment. * indicates significance p < 0.05 compared to ovary-intact rats; † indicates significance p < 0.05 compared to ovx rats as determined by one-way ANOVA followed by Student–Newman–Keuls post hoc analysis