TABLE 3.

V_HH families based on CDR3 similarity^a

Familyb	Member(s)	Specificityc
JIV-F6	V1B10, V1D3	A
JIY-A7	JNM-G4	A
JIY-D9	V2B8	A
V1C7	V2B9, V2E8, V5C1	A
V2G10	V1G6	A
JIZ-B7	JIW-D12, JNN-B8, JNN-D1	B
JIW-G10	JNN-A3	B′
V2C11	V2D4, V5H2	B

^aBold and underlined data indicate a V_HH with strong TNA; bold data indicate moderate TNA; underlined data indicate weak TNA.

^bA family was defined as composed of two or more V_HHs having CDR3 sequences of equal lengths and >90% identity at the nucleotide level.

^cA, RTA; B, RTB; B′, plate-bound RTB.