Figure 6.

Estimation using the data obtained under low S _T and high S _T together. (a) Posterior samples are inferred using data sets from S _T = 0.2 nM (Fig. S1 left) and S _T = 80 nM (Fig. S1 right) together for either E _T = 0.2, 2, or 40 nM. When E _T is low, both the sQ and the tQ models allow accurate and precise estimation. As E _T increases, the estimates obtained with the sQ model become inaccurate, and the estimates of K _M obtained with the tQ model become less precise, similar to the single-parameter estimation (Fig. 2). Here, green triangles represent the true values of k _cat or K _M. (b) The scatter plots of the posterior samples. Here green triangles, blue circles, and red squares represent true values, posterior means of the sQ model, and those of the tQ model, respectively.