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. 2017 Dec 5;7:16956. doi: 10.1038/s41598-017-17034-5

Table 2.

PD-L1 IHC scoring according to the 22C3-IHC assay scoring algorithm.

SP142-IHC assay Total Kappa value P value McNemar-Bowker
0 1+ 2+
22C3-IHC assay 0 89 1 0 90 0.481P < 0.001 P < 0.001
1+ 16 9 0 25
2+ 4 9 7 20
Total 109 19 7 135

0 indicates negative, 1 + weakly positive, and 2 + strongly positive PD-L1 expression.