TABLE 3 .
Infant fecal HMO profiles at baseline (postnatal day 6) and postnatal day 29
| HMOa | Mean (SD) HMO concn (mg/ml) |
Adjusted P valueb |
|||
|---|---|---|---|---|---|
| CON on: |
EVC001-fed on: |
||||
| Day 6 (n = 32) |
Day 29 (n = 32) |
Day 6 (n = 34) |
Day 29 (n = 34) |
||
| 1101 | 0.16 (0.25) | 0.08 (0.13) | 0.1 (0.09) | 0 (0.01) | 0.0664 |
| 2001 | 6.37 (4.45) | 5.12 (5.34) | 5.07 (4.55) | 0.39 (1.91) | 0.0056 |
| 2020 | 0.45 (0.43) | 0.6 (0.59) | 0.69 (0.84) | 0.08 (0.23) | 0.0688 |
| 2-FL | 1.97 (1.93) | 2.01 (2) | 1.57 (1.94) | 0.03 (0.14) | 0.0034 |
| 3000 | 0.68 (1.36) | 0.53 (1.55) | 1.3 (2.34) | 0.01 (0.02) | 0.4457 |
| 3100 | 7.88 (6.79) | 7.56 (11.15) | 7.35 (8.15) | 0.47 (1.54) | 0.0664 |
| 3101 | 4.25 (2.81) | 2.16 (1.67) | 3.11 (2.35) | 0.1 (0.43) | 0.0034 |
| LNFP I | 9.62 (7.41) | 6.71 (7.08) | 5.97 (6.43) | 0.24 (1.27) | 0.0056 |
| LNFP III, IV, V |
4.97 (2.72) | 5.71 (3.73) | 3.75 (3.13) | 0.12 (0.4) | <0.0001 |
| 3111 | 0.05 (0.05) | 0.03 (0.04) | 0.06 (0.07) | 0.00 (0) | 0.2198 |
| 3120 | 0.84 (0.66) | 1.15 (1.08) | 0.77 (0.66) | 0.04 (0.14) | 0.0001 |
| 3′-FL | 0.99 (0.88) | 2.27 (2.06) | 1.23 (1.28) | 0.05 (0.18) | 0.0001 |
| 4200 | 0.7 (0.79) | 1.23 (1.92) | 0.76 (1.36) | 0.39 (0.45) | 0.2198 |
| 4201 | 1.24 (1.29) | 0.96 (1.4) | 0.89 (0.85) | 0.09 (0.34) | 0.0607 |
| 4210 | 1.96 (1.35) | 2.61 (2.46) | 1.66 (1.82) | 0.3 (0.55) | 0.0015 |
| 4211 | 1.34 (0.95) | 1.55 (1.6) | 1.13 (1.01) | 0.13 (0.55) | 0.0015 |
| 4220 | 1.01 (0.56) | 1.53 (1.01) | 0.79 (0.6) | 0.11 (0.23) | <0.0001 |
| 4221 | 0.1 (0.09) | 0.07 (0.11) | 0.06 (0.06) | 0.01 (0.02) | 0.046 |
| 4230 | 0.21 (0.21) | 0.4 (0.45) | 0.18 (0.21) | 0.02 (0.05) | 0.0014 |
| 4300 | 0.28 (0.2) | 0.25 (0.28) | 0.18 (0.29) | 0.82 (0.99) | <0.0001 |
| 5301 | 0.14 (0.12) | 0.08 (0.13) | 0.09 (0.08) | 0.02 (0.03) | 0.2198 |
| 5310 | 0.94 (0.58) | 0.92 (0.95) | 0.76 (0.87) | 0.4 (0.44) | 0.1916 |
| 5311 | 0.26 (0.19) | 0.12 (0.12) | 0.18 (0.18) | 0.01 (0.03) | 0.0664 |
| 5320 | 0.97 (0.61) | 0.95 (0.89) | 0.69 (0.65) | 0.26 (0.25) | 0.0117 |
| 5321 | 0.1 (0.08) | 0.07 (0.06) | 0.07 (0.07) | 0 (0.01) | 0.0047 |
| 5330 | 0.28 (0.31) | 0.37 (0.39) | 0.29 (0.32) | 0.13 (0.17) | 0.0838 |
| 5331 | 0.02 (0.02) | 0.01 (0.01) | 0.01 (0.01) | 0 (0) | 0.2198 |
| 5340 | 0.06 (0.05) | 0.06 (0.06) | 0.05 (0.06) | 0.02 (0.03) | 0.1282 |
| 6401 | 0.05 (0.06) | 0.03 (0.05) | 0.04 (0.06) | 0.01 (0.01) | 0.2674 |
| 6410 | 0.41 (0.34) | 0.47 (0.61) | 0.36 (0.51) | 0.31 (0.36) | 0.4457 |
| 6420 | 0.28 (0.25) | 0.36 (0.39) | 0.22 (0.25) | 0.18 (0.18) | 0.2198 |
| 6430 | 0.1 (0.09) | 0.06 (0.07) | 0.06 (0.07) | 0.01 (0.03) | 0.0896 |
| 6440 | 0.06 (0.05) | 0.06 (0.05) | 0.04 (0.04) | 0.01 (0.02) | 0.0023 |
| Total | 48.74 (23.79) | 46.08 (26.78) | 39.48 (28.42) | 4.75 (8.6) | <0.0001 |
a
2′-FL, 2′-fucosyllactose; 3′-FL, 3′-fucosyllactose; LNFP, lacto-N-fucosyllpentose. The structural formula for unnamed structures is hexose | hexose-N-acetylglucosamine/galactosamine | fucose | sialic acid.
b
Day 29 results were compared with a multiple t test with the Holm-Sidak correction.