Figure 2.

Schematic of the NDE1/miR-484 locus, and summary of findings from this study. The exonic structure of the NDE1 gene and the relative location of miR-484, both on the + strand of chromosome 16p13.11. For NDE1, exons present in all transcripts encoding full-length (300 amino acid or longer) NDE1 protein are filled in with solid colour, while optionally transcribed exons are indicated with a striped pattern. The SNPs genotyped in the large Finnish family cohort are labelled, with the LD block structure summarized (detail in electronic supplementary material, figure S3). SNPs analysed in this study are labelled in bold type, with those SNPs that could only be studied in one of the sub-cohorts being further indicated with italics.