Table 2.

Results for the association of NDE1 variants with groups of medications based on their metabolism by the CYP2C19 enzyme and/or selective serotonin reuptake inhibitor (SSRI) class status, showing the p-values and odds ratios (and 95% CIs) for the interaction model. p-Values ≤ 0.01 are below the Bonferroni correction threshold for the five groups tested. p-Values and their respective ORs that are below the Bonferroni threshold are in bold. Medications included in each group analysis can be found in the electronic supplementary material, figure S4 and table S3.

NDE1 variant	SNP	SNP × gender
	p-value	p-value	OR (95% CI)
all psychoactive drugs metabolized by CYP2C19 (N = 510–581, no. of instances: 843–945)
rs4781678	0.79	0.90	0.97 (0.55–1.69)
rs2242549	0.56	0.74	1.10 (0.64–1.86)
rs881803	0.29	0.15	1.53 (0.86–2.73)
rs2075512	0.64	0.79	0.93 (0.53–1.63)
haplotype	0.35	0.73	1.10 (0.63–1.93)
SSRIs (N = 357–402, no. of instances: 496–563)
rs4781678	0.31	0.033	0.43 (0.20–0.93)
rs2242549	0.92	0.031	0.46 (0.23–0.93)
rs881803	0.41	0.29	0.67 (0.32–1.40)
rs2075512	0.97	0.010	0.37 (0.17–0.79)
haplotype	0.87	0.029	0.42 (0.19–0.91)
SSRIs metabolized by CYP2C19 (N = 282–318, no. of instances: 357–395)
rs4781678	0.42	0.003	0.27 (0.11–0.64)
rs2242549	0.47	0.006	0.30 (0.13–0.70)
rs881803	0.51	0.064	0.44 (0.19–1.05)
rs2075512	0.39	0.005	0.31 (0.13–0.70)
haplotype	0.95	0.006	0.30 (0.13–0.71)
SSRIs not metabolized by CYP2C19 (N = 123–145, no. of instances: 142–169)
rs4781678	0.48	0.71	1.36 (0.27–6.87)
rs2242549	0.30	0.58	1.37 (0.45–4.23)
rs881803	0.58	0.23	2.24 (0.60–8.38)
rs2075512	0.10	0.88	0.88 (0.19–4.13)
haplotype	0.66	0.77	1.25 (0.27–5.76)
non-SSRIs metabolized by CYP2C19 (N = 318–355, no. of instances: 411–459)
rs4781678	0.24	0.0051	3.33 (1.44–7.73)
rs2242549	0.62	0.0013	3.42 (1.61–7.25)
rs881803	0.63	0.00030	5.82 (2.25–15.0)
rs2075512	0.92	0.0064	3.63 (1.44–9.17)
haplotype	0.22	0.00030	4.93 (2.07–11.76)