Figure 5.

Growth control by mechanical feedbacks. (a) Illustration of the model developed in [110]. The Drosophila wing disc pouch is shown as an idealized circle here. At the beginning, most growth occurs in the centre of the disc (left, dark red indicating a higher growth rate). As the discs grows, lateral cells get stretched (green), inducing growth in this region. This is, however, insufficient to compensate for the stretching. Therefore, the centre of the disc gets compressed (blue), reducing the growth rate. Growth terminates once cells cannot anymore overcome the inhibitory effect by the compression. (b) Distribution of hydrostratic pressure differences, ΔP, in a wing disc, as inferred from the cell geometries: the hydrostatic pressure difference is higher in the centre of the wing disc than in the periphery; the values were normalized such that average pressure difference in the tissue is zero (colour bar). Adapted from Ishihara & Sugimura [112]. Reprinted with permission from Elsevier. Scale bar, 20 µm.