Figure 1.

Overall structure of the human APC/C^Cdh1.Emi1 complex. (a) and (b) Two orthogonal views of the APC/C. Large APC/C subunits are represented as cartoons, whereas small APC/C subunits (Apc12, Apc13, Apc15, Apc16), the IR tails of Cdh1 and Apc10, the Cdh1 NTD and the Emi1 inhibitor are shown as space filling representations. The TPR and platform sub-structures are labelled. The two subunits of the canonical homo-dimeric TPR subunits (Apc3, Apc6, Apc7 and Apc8) and Apc12 are labelled with the suffix ‘A’ and ‘B’. Apc2^CTD and Apc11^RING form the catalytic module, Cdh1 and Apc10 generate the substrate recognition module. PDB 4UI9, from Chang et al. [80].