Figure 11.

APC/C regulation by the MCC. (a) Atomic structure of APC/C^MCC. Ordered regions of BubR1 C-terminal to the TPR domain are shown in space-filling representation, as is the NTD and IR tail of Cdc20^MCC. (b) Schematic of BubR1 showing positions of D-box (D1, D2), KEN-box (K1, K2) and ABBA motifs (A1–A3) and schematic of Cdc20. (c) Details of the MCC-Cdc20^APC/C module with BubR1 forming extensive interactions with Cdc20^MCC and Cdc20^APC/C. (d) Schematic of interactions formed by Cdc20^MCC and Cdc20^APC/C with BubR1 and APC/C subunits. PDB 5LCW, from Alfieri et al. [92].